Lettuce – Downy mildew

Crop(s):          Lettuce

Disease(s):     Downy mildew

Resistance management strategy for:

Group 4 Phenylamides (PA);
Group 28+43 Carbamates + benzamides;
Group 40 Carboxylic acid amides (CAA);
Group 45+40 Quinone outside inhibitors, stigmatellin binding type (QoSI) + CAA;
Group 49 Oxysterol binding protein inhibitors (OSBPI); and
Group 49+11 OSBPI + quinone outside inhibitors (QoI).


  1. Applications made within the nursery count towards the total number of applications allowed per crop. It is recommended that disease control is started early and maintain a regular program using a fungicide from groups other than Group 4, 40, 45+40, 49 (or 49+11) or 28+43.
  2. When conditions favour disease development, do not wait for disease to appear, but apply two consecutive sprays of a Group 4, 40, 49, 49+11 or 28+43 product at the interval recommended on the label. Then resume the program of sprays using an alternative fungicide group to what was just applied.
  3. Do not apply more than four sprays of a Group 4 or 40 product per season.
  4. Do not apply more than four sprays of a Group 45+40 product per crop.
  5. Apply Group 45+40 fungicides preventatively.
  6. Group 49 including Group 49+11 fungicides should only consist of a maximum of one in every three of the total fungicide sprays per crop targeting downy mildew. Do not apply more than three sprays of a Group 49 containing product including Group 49+11 sprays per crop. Group 49+11 sprays count as both a Group 49 and a Group 11
  7. Do not apply more than three sprays of a Group 28+43 product per crop.
  8. Apply Group 4 and 49 (or 49+11) fungicides preventatively and only in mixtures or co-formulations with a registered fungicide from a different mode of action group, with no known resistance.
    1. Continue alternation of fungicide modes of action between successive crops. Do not make more than (6) six total applications of a Group 49 product on multiple crops per year, on the same area, targeting the same disease.
    4 28+43 40, 45+40 49, 49+11
    Maximum number of consecutive applications 2 2 2 2
    Maximum number of solo sprays None     None of 49
    Maximum number of sprays per crop or season including nursery * 4 3^

    (or 1 in 3)

    2 or 4 3 ^

    (or 1 in 3)

    6 per year

    * Maximum application number on product label may differ. Ensure you follow the label recommendations

    ^Not allowed in nursery situations

URL: https://croplife.org.au/resources/programs/resistance-management/lettuce-downy-mildew-3/
Content last updated: June 26, 2024

CropLife Australia’s Resistance Management Strategies provide a guide for crop protection product rotation through product groups. The strategies are a useful tool that supports farmers’ adoption of resistance management. All crop protection products must be handled and applied strictly as specified on the product label or APVMA permits.

These Resistance Management Strategies do not replace product labels. They are a guide only and do not endorse particular products, groups of products or cultural methods in terms of their performance. It is important to check with the Australian regulator’s (APVMA) product database for contemporary information on products and active constituents. The database can be sourced through www.apvma.gov.au

The information given in this strategy is provided in good faith and without any liability for loss or damage suffered as a result of its application and use. Advice given in this strategy is valid as at 26 June 2024. All previous versions of this strategy are now invalid.